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Clinical Features of Post-Parturient Hemoglobinuriain Dairy Cattle and Buffaloes: A Review

DOI: 10.4236/ojvm.2021.114010, PP. 143-155

Keywords: Hypophosphatemia, Anemia, Post-Partum Hemoglobinuria, Cattle and Buffalo

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Postpartum hemoglobinuria (PPH) is a sporadic noninfectious syndrome which normally seen in bovine around the world. PPH is most commonly affecting high-productive cows and buffaloes during the early pregnancy and early lactation period. PPH stands as a serious threat to the dairy cattle and buffaloes in Afghanistan, Pakistan, and India, affecting a considerable number of animals every year. It is characterized by hemoglobinuria, intravenous hemolysis, severe anemia, and death due to anemia and hypoxia. However, the exact mechanism of the mentioned illness is not completely understood. Lots of comprehensive studies have been done and/or still are in progress in order to find the exact causes of intravascular hemolysis that is responsible for hemoglobinuria in the mentioned disease. But, hypophosphatemia in the high productive milking cows during the early stage of milk production is widely confident to be associated with PPH. In different parts of the world, many risk factors had been reported to be associated with PPH. Decreasing the level of phosphorous in blood serum, interrupted the phospholipid layers of red blood cells resulting in hemoglobinuria, a decrease in milk production, anorexia, and the death of animals in the cause if remained untreated. Urinalysis and hematology findings are the most commonly suitable diagnostic tools for this disease. Lots of studies have been suggesting that injection of sodium acid phosphate along with important minerals and supportive therapy with anti-oxidants can be used as the therapeutic protocol for the management o


[1]  Sharma, V., Kumar, H., Kumar, S. and Yadav, M. (2020) Therapeutic Management of Post-Parturient Haemoglobunuria in Buffalo: A Case Report. The Pharma Innovation Journal, 9, 299-301.
[2]  Radostits, O.M., Gay, C.C., Hinchcliff, K.W. and Constable, P.D. (2007) Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats. Third Edition, Elsevier, Amsterdam, 1682-1683.
[3]  Moore, F. (1997) Serum Chemistry in Dairy Cows—A Herd Management Tool. Veterinary Medical, 92, 986-991.
[4]  Whitaker, D.D., Goodger, W.J., Garcia, M., et al. (1999) Use of Metabolic Profiles in Dairy Cattle in Tropical and Subtropical Countries on Small Holder Dairy Farms. Preventive Veterinary Medicine, 38, 119-131.
[5]  Zhang, Z., Bi, M., Yang, J., Yao, H., Liu, Z. and Xu, S. (2017) Effect of Phosphorus Deficiency on Erythrocytic Morphology and Function in Cows. Journal of Veterinary Science, 18, 333-340.
[6]  Kumar, A., Kumar, M. and Haque, S. (2010) Treatment of Hemoglobinuria in Cattle. Indian Veterinary Journal, 78, 510-512.
[7]  Macwilliams, P.S., Searcy, G.P. and Bellamy, J.E. (1982) Bovine Postparturient Hemoglobinuria: A Review of the Literature. Canadian Veterinary Journal, 23, 309-312.
[8]  Ogawa, E., Kobayashi, K., Yoshiura, N. and Mukai, J. (1987) Bovine Post-Partureint Hemglobinuria Hypophsophatemia and Metabolic Disorder in Red Blood Cells. American Journal of Veterinary Research, 48, 1300-1303.
[9]  Akhtar, M.Z., Khan, A., Khan, M.Z. and Muhammad, G. (2007) Hemato-Biochemical Aspects of Parturient Hemoglobinuria in Buffalo. Turkish Journal of Veterinary and Animal Sciences, 1, 119-123.
[10]  Resum, N.S., Kour, P., Singh, H. and Sharma, N. (2017) Post-Partum Hemoglobinuria (PPH) in Bovine. Theriogenology Insight—An International Journal of Reproduction in All Animals, 7, 51.
[11]  Ok, M., Guzelbektes, H., Sen, I., Coskun, A. and Ozturk, A.S. (2009) Post-Parturient Haemoglobinuria in Three Dairy Cows. A Case Report. Bulletin—Veterinary Institute in Pulawy, 53, 421-423.
[12]  Bradford, P.S. (2002) Large Animal Internal Medicine. Mosby, London, 303-304.
[13]  Senthil Kumar, A., Sri Balaji, N. and Uma Rani, R. (2014) Acute Post-Parturient Hemoglobinuria in a Cross Bred Dairy Cow. International Journal of Agricultural Sciences and Veterinary Medicine, 2, 1-3.
[14]  Saed Albayati, O.A.S. and Luaibi, O.K. (2020) Study of Hemato-Biochemical Changes in Post-Parturient Hemoglobinurea in Iraqi Local Cows. Plant Archives, 20, 584-588.
[15]  Radwan, M.E. and Rateb, H.Z. (2007) Clinical, Haematological and Some Biochemical Variations Hypophosphataemia in Buffaloes before and after Treatment at Assiut Government. Beni-Suef Veterinary Medical Journal, 17, 35-41.
[16]  Iqbal, I., Mustafa, G., Tripathi, A.K. and Soodan, J.S. (2011) Post-Parturient Hemoglobinuria in a Buffalo: A Case Report. International Journal of Livestock Research, 1, 59-63.
[17]  Gocher, P.T., Chaudhary, A.K., Arora, A.S., Gaur, M., et al. (2018) Perspectives of Parturient Hemoglobinuria (Pph) in Buffaloes. International Journal of Development Research, 8, 23513-23520.
[18]  Deeba, F., Sarwar, A. and Qaiser, Q. (2019) Investigations on Copper and Phosphorus Deficiency Associated Post-Parturient Hemoglobinuria in Dairy Animals and Clinical Management with Antioxidants. Journal of Entomology and Zoology Studies, 7, 426-431.
[19]  Neto, B.J.D., Oliveira, C.C.M., Durate, M.D., Albernaz, C.A., Correa, G.R. and Correa, F.R. (2007) Phosphorous Deficiency in Buffaloes in the State of Para Northern Brazil. Italian Journal of Animal Science, 6, 971-973.
[20]  Sivakanesan, R. (1999) Metabolic Diseases, Water Buffalo in Asia Sarec/Naresa Publication. Sarec/Naresa Publication 45, 107-117.
[21]  Dalir-Naghadeh, B., Seifi, H.A., Asri-Rezaei, S. and Pilevery, N. (2006) Post-Parturient Hemoglobinuria in Iranian River Buffaloes: A Preliminary Study. Comparative Clinical Pathology, 14, 221-225.
[22]  Najarnezhad, V., Jalilzadeh-Amin, G., et al. (2016) Post Parturient Hemoglobinuria in a Sheep Flock. Journal of the Hellenic Veterinary Medical Society, 67, 265-268.
[23]  Soren, S., Srivastava, M., Kachhawa, J.P. and Soren, P. (2015) Clinical Study on Post-Partum Hemoglobinuria in Buffaloes. Intas Polivet, 15, 518-522.
[24]  Purohit, G.N., Ruhil, S., Daga, M., Gaur, M., Bihani, D.K. and Ahuja, A. (2014) Parturition Related Metabolic Disorder in Buffaloes: A 10 Year Case Analysis. Ruminant Science, 3, 123-126.
[25]  Goff, J.P. (2000) Pathology of Calcium and Phosphorous Disorders. Veterinary Clinics of North America: Food Animal Practice, 16, 319-337.
[26]  Stockdale, C.R., Moyes, T.E. and Dyson, R. (2005) Acute Post-Parturient Hemoglobinuria in Dairy Cows and Phosphorous Status. Australian Veterinary Journal, 83, 362-366.
[27]  Mahmood, A., Khan, M.A., Younus, M., Khan, M.A., et al. (2012) Case Control Study of Parturient Hemoglobinuria in Buffaloes. Pakistan Veterinary Journal, 32, 375-377.
[28]  Grunberg, W., Mol, J.A. and Teske, E. (2015) Red Blood Cell Phosphate Concentration and Osmotic Resistance during Dietary Phosphate Depletion in Dairy Cows. Journal of Veterinary Internal Medicine, 29, 395-399.
[29]  Malik, H.U. and Samad, A. (1996) Pathogenesis of Phosphorous Deficiency Haemoglobinuria in Buffaloes. Influence of Extracellular Inorganic Phosphorous on Glucose Metabolism in Buffalo Erythrocytes. Buffalo Journal, 12, 73-84.
[30]  Jubb, T.F., Jerrett, I.V., Browning, J.W. and Thomas, K.W. (1990) Haemoglobinuria and Hypophosphataemia in Postparturient Dairy Cows without Dietary Deficiency of Phosphorus. Australian Veterinary Journal, 67, 86-89.
[31]  Ghoke, S. and Animal, M. (2018) A New Approach in Clinical Management of Phosphorous Deficiency Hemoglobinuria (PDH) in Buffaloes. Intas Polivet, 15, 485-496.
[32]  Radostits, O.M., Gay, C.C., Hinchcliff, K.W. and Constable, P.D. (2000) Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats. Saunders Elsevier, London, 1700-1793.
[33]  Wang, X.L., Gallagher, C.H., Mc Clure, T.J., Reef, V.E. and Canfield, P.J. (1985) Bovine Post-Parturient Hemoglobinuria: Effective of Inorganic Phosphate on Red Blood Cells Metabolism. Research in Veterinary Science, 39, 333-339.
[34]  Madheswaran, R. (2018) Clinico-Pathological Features of Post Parturient Haemoglobinuria in She Buffaloes. Indian Veterinary Journal, 94, 49-51.
[35]  Akhtar, Z.M., Khan, A., Khan, M.Z., et al. (2008) Patho-Biochemical Change in Buffaloes (Bubalus bubalis) Suffering from Parturient Hemoglobinuria. Pakistan Veterinary Journal, 28, 139-143.
[36]  Sharma, S.K., Monika, J., Diler, S. and Khosa, S.K. (2014) A Hemato-Biochemecal and Therapeutic Study of Post-Parturient Hemoglobinuria in Buffaloes. Indian Journal, 15, 523-525.
[37]  Akhtar, M.Z., Khan, A., Zaman, T. and Aham, N. (2006) Clinico-Epidemiological and Biochemical Observation of Parturient Hemoglobinuria in Nili Ravi Buffaloes (Bubalus bubalis). Pakistan Veterinary Journal, 1, 151-156.
[38]  Reddy, B.S.S., Reddy, B.S., Venkatasivakumat, R. and Sivajothi, S. (2014) Hemoglobinuria Due to Hypophosphatemia in Last Trimester Pregnant Buffalo. International Journal of Biological Research, 2, 153-155.
[39]  Wakayo, B.U., Varughese, E., Hospital, B.P., Mall, D., Brar, P., Angad, G., et al. (2013) Diagnosis and Treatment of Postparturient Haemoglobinurea in Buffalo: A Case Report.
[40]  Alvi, M.A., Ahmad, S., Aqib, A.I., Tayyab, M.H., Murtaza, A., Ashfaq, K., et al. (2018) Diagnosing Post Parturient Hemoglobinuria in Goat on the Basis of Hematology, Serum Biochemistry and Treatment Response. Matrix Science Medica, 2, 34-36.
[41]  Durrani, A.Z., Kamal, N., Shakoori, A.R. and Younus, R.M. (2010) Prevalence of Post Parturient Haemoglobinuria in Buffalo and Therapeutic Trials with Toldimfos Sodium and Tea Leaves in Pakistan. Turkish Journal of Veterinary and Animal Sciences, 34, 45-51.
[42]  Smith, B. (1973) Copper and Molybdenum Imbalance in Relationship to Post-Parturient Hemoglobinuria in Cattle. New Zealand Veterinary Journal, 21, 240-245.
[43]  Rana, Y.S., Singh, R. and Beniwal, B.S. (2006) Clinico-Biochemical and Therapeutic Studies in Post-Parturient Hemoglobinuria in Buffaloes. Haryana Veterinarian, 45, 38-40.
[44]  Bhikane, A.U., Ghoke, S.S., Masar, P.S., Salunke, V.M., et al. (2011) A New Approach in Clinical Management of Phosphorous Deficiency Hemoglobinuria in Buffaloes. Animal Science Journal, 12, 56-58.
[45]  Muhammad, G., Saqib, M. and Athar, M. (2001) A Rational Approach to Diagnosis, Treatment and Control of Parturient Haemoglobinuria (Red Water) in Buffaloes and Cattle. Pakistan Veterinary Journal, 21, 214-219.


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