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异位辅助性肝移植的研究进展
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Abstract:
异位辅助性肝移植比起原位肝移植有着许多独有的优势,其在急性肝衰竭、遗传代谢性肝病、终末期肝病等治疗上进步显著。但是腹腔空间的缺乏、门静脉血流竞争导致移植肝衰竭、移植早期的急性排斥反应等难题,阻碍了该术式更好的发展。本文就异位辅助性肝移植的目前现状及难点问题作一综述,以期进一步增加对异位辅助性肝移植的认识,为肝移植开拓新的思路。
Heterotopic auxiliary liver transplantation has many unique advantages over orthotopic liver transplantation in the treatment of acute liver failure, inherited metabolic liver disease, end stage liver disease and so on. However, the lack of abdominal space, portal vein blood flow competition lead to graft failure, early acute rejection and other problems, which hinder the better development of this technique. This article reviews the current status and difficulties of heterotopic auxiliary liv-er transplantation, in order to improve the understanding of heterotopic auxiliary liver transplan-tation and open up a new way for liver transplantation.
[1] | Welch, C.S. (1955) A Note on Transplantation of the Whole Liver in Dogs. Transplantation Bulletin, 2, 54-55. |
[2] | Absolom, K.B., Hagihara, P.F. and Griffen, W.D. (1965) Experimental and Clinical Heterotopic Liver Homotransplantation. Rev Int Hepatol, 15, 1481-1490. |
[3] | 夏穗生. 我国肝移植现状和展望[J]. 现代实用医学, 2002, 14(2): 55-57. |
[4] | Stravitz, R.T. and Lee, W.M. (2019) Acute Liver Failure. The Lancet, 394, 869-881.
https://doi.org/10.1016/S0140-6736(19)31894-X |
[5] | Kou, J.T., Liu, Z., Zhu, J.Q., et al. (2020) Research on Clinical Efficacy of Liver Transplantation for Severe Liver Disease. Organ Transplantation, 11, 482-486. |
[6] | 高丹等. 辅助性部分原位肝移植治疗小鼠急性肝功能衰竭[J]. 中华器官移植杂志, 2018, 39(12): 745-749. |
[7] | 翁建平. MLD的定义与分类探讨[J]. 中华医学杂志, 2020, 100(6): 104-106. |
[8] | 陈淑如, 崇雨田, 李新华. 遗传代谢性肝病的临床基因诊断[J]. 中华肝脏病杂志, 2018, 26(12): 894-897. |
[9] | Li, C.Y. and Lai, L.S.C. (2015) Retrospective Observation of Therapeutic Effects of Adult Auxiliary Partial Living Donor Liver Transplantation on Postpartum Acute Liver Failure: A Case Report. World Journal of Gastroenterology, 21, 2840-2847. https://doi.org/10.3748/wjg.v21.i9.2840 |
[10] | 傅斌生, 张彤, 等. 肝移植治疗肝豆状核变性的单中心疗效分析[J]. 器官移植, 2011, 2(2): 64-67. |
[11] | 尤楠, 等. 脾窝异位辅助性部分肝移植治疗遗传代谢性肝病的临床研究进展[J]. 中华器官移植杂志, 2012, 33(8): 506-508. |
[12] | 贾亚男, 等. 危重症肝病肝移植患者诊断和评估标准的临床进展[J]. 器官移植, 2020, 11(3): 326-331, 368. |
[13] | Parikh, N.D. and Agopian, V.G. (2019) Moving toward Personalizing MELD Exceptions in Liver Transplantation for Hepatocellular Carcinoma. Transplant International, 10, 2153-2154. https://doi.org/10.1111/ajt.15389 |
[14] | 王少发, 等. 辅助性左肝移植治疗高MELD评分肝硬化患者[J]. 实用器官移植电子杂志, 2020, 8(6): 477-480. |
[15] | 汪博, 等. 肾移植围手术期容量管理研究进展[J]. 肾脏病与透析肾移植杂志, 2020, 29(5): 96-100. |
[16] | Olausson, M., Mjornstedt, L., Norden, G., et al. (2007) Successful Combined Partial Auxiliary Liver and Kidney Transplantation in Highly Sensitized Cross Match Positive Recipients. American Journal of Transplantation, 7, 130-136. https://doi.org/10.1111/j.1600-6143.2006.01592.x |
[17] | Ingelsten, M., Karlsson-Parra, A., Granqvist, A.B., et al. (2011) Postischemic Inflammatory Response in an Auxiliary Liver Graft Predicts Renal Graft Outcome in Sensitized Patients. Transplantation, 91, 888-894.
https://doi.org/10.1097/TP.0b013e3182100f19 |
[18] | 李宁, 等. LUMINEX技术在高致敏肾移植受者中的应用[J]. 中国药物与临床, 2020, 20(15): 2557-2559. |
[19] | 朱元宏, 袁建林, 张更. 肾移植联合辅助性肝移植治疗高致敏受者的研究进展[J]. 中华器官移植杂志, 2015, 36(1): 59-61. |
[20] | Dokmak, S., Elkrief, L. and Belghiti, J. (2013) Auxiliary Liver Transplantation with a Small Deceased Liver Graft for Cirrhotic Liver Complicated by Hepatocellular Carcinoma. Transplant International, 26, e102-e104.
https://doi.org/10.1111/tri.12173 |
[21] | Line, P.D., et al. (2015) A Novel Concept for Partial Liver Transplantation in Nonresectable Colorectal Liver Metastases: The RAPID Concept. Annals of Surgery, 262, e5-e9. https://doi.org/10.1097/SLA.0000000000001165 |
[22] | Schaefer, B., Zoller, H. and Schneeberger, S. (2018) Con: Liver Transplantation for Expanded Criteria Malignant Diseases. Liver Transplantation, 24, 104-111. https://doi.org/10.1002/lt.24975 |
[23] | Ekser, B., Echeverri, G.J., Hassett, A.C., et al. (2010) Hepatic Function after Genetically Engineered Pig Liver Transplantation in Baboons. Transplantation, 90, 483-493. https://doi.org/10.1097/TP.0b013e3181e98d51 |
[24] | Yeh, H., Machaidze, Z., Wamala, I., et al. (2014) Increased Transfusion-Free Survival Following Auxiliary Pig Liver Xenotransplantation. Xenotransplantation, 21, 454-464. https://doi.org/10.1111/xen.12111 |
[25] | Li, Q., Hara, H., Zhang, Z., et al. (2018) Is Sensitization to Pig Antigens Detrimental to Subsequent Allotransplantation? Xenotransplantation, 25, e12393. https://doi.org/10.1111/xen.12393 |
[26] | 李霄, 等. 异种肝移植手术前后移植肝差异表达基因的筛选及验证[J]. 实用器官移植电子杂志, 2018, 6(5): 27-32. |
[27] | 张雪平, 等. 部分脾动脉栓塞术治疗肝硬化脾功能亢进患者后免疫变化研究进展[J]. 介入放射学杂志, 2020, 29(9): 958-961. |
[28] | 朱志军, 曾志贵. 辅助性肝移植的研究进展[J]. 临床肝胆病杂志, 2015, 31(12): 2020-2022. |
[29] | 陈晓鹏, 等. 可量化的受体门静脉干预调节猪辅助性部分肝移植两肝门静脉血流竞争[J]. 中华实验外科杂志, 2008, 25(11): 1407-1409. |
[30] | 郭少华, 等. 不同门静脉灌注条件对肝细胞增殖的影响[J]. 医学临床研究, 2019, 36(1): 145-147. |
[31] | Erhard, J., Lange, R., Rauen, U., Scherer, R., Friedrich, J., Pietsch, M., et al. (1998) Auxiliary Liver Transplantation with Arterialization of the Portal Vein for Acute Hepatic Failure. Transplant International, 11, 266-271.
https://doi.org/10.1111/j.1432-2277.1998.tb00968.x |
[32] | 田全发, 等. 双重动脉血供对肝再生线粒体能量代谢的影响[J]. 中华实验外科杂志, 2020, 37(10): 1834-1837. |
[33] | 孙志为, 王天朝, 莫一我, 等. 脾切除脾窝异位辅助减体积肝移植治疗终末期肝病的临床研究[Z]. 2009. |
[34] | 金昊, 等. 供受者肝重量比对大鼠部分肝移植后排斥反应的影响[J]. 中华器官移植杂志, 2018, 39(2): 96-103. |
[35] | 熊辉. 大鼠HALT术后PFP mRNA的表达[J]. 江西医药, 2010, 45(12): 1177-1180. |