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Medical Diagnosis 2021
PCSK9与肿瘤发生发展关系的研究进展
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Abstract:
前蛋白转化酶枯草溶菌素9 (PCSK9)是一种新的前蛋白转换酶，属于枯草蛋白酶亚家族，主要功能是降解低密度脂蛋白受体影响LDL的代谢，已经证实是治疗心血管疾病的有效靶点。随着对PCSK9研究的深入，PCSK9过表达还可引起细胞周期、凋亡、炎症及应激反应等多条通路失调，与肿瘤密切相关。本文旨在探讨PCSK9在肿瘤发生发展中作用的相关性。
Proprotein convertase subtilisin kexin 9 (PCSK9) is a new protein converting enzyme, belonging to the subfamily of subtilase, whose function is to degrade low density lipoprotein receptor to affect LDL metabolism, which has been proved to be an effective target for the treatment of cardiovascular diseases. With the further study on PCSK9, over-expression of PCSK9 can also cause dysregulation of multiple pathways such as cell cycle, apoptosis, inflammation and stress response, which is closely related to tumors. The purpose of this study was to investigate the correlation of PCSK9 in tumor development.
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