|
|
纳米银表面增强拉曼光谱法快速检测艾司唑仑
|
Abstract:
目的：建立安眠药中非法添加艾司唑仑的表面增强拉曼光谱分析方法。方法：利用正交实验确定最佳检出条件，结合拉曼图谱对艾司唑仑的特征峰进行分析，建立艾司唑仑快速检测的定性定量识别模型。结论：以艾司唑仑683 cm？1处的特征峰强度建立标准曲线方程，检出限为0.1 μg？mL？1。本方法的简便操作和较低成本为现场快速检验安眠药中艾司唑仑非法添加成分提供了新方法。
Objective: To establish a surface-enhanced Raman spectroscopy method for the analysis of illegally added eszopiclone in sleeping pills. Methods: To determine the best detection conditions using orthogonal experiments, to analyze the characteristic peaks of eszopiclone in combination with Raman mapping, and to establish a qualitative and quantitative identification model for the rapid detection of eszopiclone. Conclusion: A standard curve equation was established with the characteristic peak intensity of eszopiclone at 683 cm？1, and the detection limit was 0.1 μg？mL？1. The simple operation and low cost of this method provide a new method for the rapid on-site inspection of the illegal addition of eszopiclone in sleeping pills.
| [1] | 李敏娜, 罗青枝, 安静, 王德松, 段彦栋. 纳米银粒子制备及应用研究进展[J]. 化工进展, 2008, 27(11): 1765-1771. |
| [2] | 方蕾, 赵晓丽, 王珺瑜, 吴爱明, 汤智, 赵天慧. 具有不同粒径和相同表面结构纳米银颗粒的制备及表征[J]. 环境科学研究, 2019, 32(5): 866-874. |
| [3] | 李静辉, 程闹闹, 刘吉成, 李莉, 贾首时. TLC-SERS法快速检测改善睡眠类保健食品中四种化学成分[J]. 光谱学与光谱分析, 2018, 38(4): 1122-1128. |
| [4] | 邓松华, 谢彪, 彭天书, 何永恒. 应用正交设计优化天马颗粒剂配方的实验研究[J]. 湖南中医药大学学报, 2018, 38(3): 266-269. |
| [5] | Quintana, J.B., Carpinteiro, J., Rodriguez, I., et al. (2004) Determination of Natural and Synthetic Estrogens in Water by Gas Chromatography with Mass Spectrometric Detection. Journal of Chromatography A, 1024, 177-185.
https://doi.org/10.1016/j.chroma.2003.10.074 |
| [6] | 姜艳彬, 单吉浩, 王莹, 蔡英华, 田亚平. LC-MS/MS技术在药物代谢研究中的应用进展[J]. 药物分析杂志, 2014, 34(3): 385-391. |
| [7] | 雷霏, 工雅晨, 孙其然, 等. 表面增强拉曼光谱在法庭科学领域的研究进展[J]. 中国司法鉴定, 2019, 105(4): 56-60 |
| [8] | Gromov, D., Pavlova, L., Savitsky, A. and Trifonov, A. (2015) Nucleation and Growth of Ag Nanoparticles on Amorphous Carbon Surface from Vapor Phase Formed by Vacuum Evaporation. Applied Physics A, 118, 1297-1303.
https://doi.org/10.1007/s00339-014-8834-0 |
