THE EFFECT OF PREPARTUM ANTIOXIDANT ADMINISTRATIONS ON BLOOD BHBA CONCENTRATION IN COWS

Objective: The presented study was aimed that investigation effect of the prepartum antioxidant administration on blood Beta-hydroxybutyric acid (BHBA) concentrations at day 7th postpartum in Holstein dairy cows. Antioxidants are defined as substances that delay or inhibits oxidative damage. Oxidantssuch as reactive oxygen species (ROS) are created as a consequence of adenosine triphosphate(ATP) production in mitochondria. Oxidants can cause tissue damage by damaging cells' macromolecules, such as DNA, proteins, and lipids. Lipids are the most sensitive macromolecule against oxidative damage. Oxidative stress can both disrupt the mechanism of insulin and induce more lipolysis. And so, ROS overproduction can enhance non‐esterified fatty acids (NEFA) and BHBA production. Material and Method:Eighty multiparous Holstein breed pregnant dairy cows were used in this study. The cows were divided into two groups astreatment (G1; n=40) and control groups (G2; n=40). In the G1, solutions containing of vitamins (A, D, E) and trace elements (Cu, Zn, Se, Mn) were performed intramuscularly at 21±5 and 10±5 days before expected parturition (280 days). In the G2, it was performed the same amounts of saline injections as a placebo. Result and Discussion: Blood BHBA levels were found that lower in the G1 group (0.73±0.20 mmol/L) compared to the G2 group (0.84±.29 mmol/L). In conclusion, it was determined that prepartum antioxidant administrations decrease blood BHBA concentration in the postpartum period in dairy cows