The Effect of Ivermectin on Serum Tnf-Α And Il-6 Levels In Bovine Papillomatosis

This study aimed to evaluate the effects of the ivermectin used in the treatment of bovine papillomatosis on serum TNF-α and IL-6. Nine cattle with different ages (15-20 months old), breed (4 male Brown Swiss, 3 female Brown Swiss, 1 female Native Black, 1 female Holstein with clinically bovine papillomatosis were included. After taking blood samples from all animals, ivermectin at a dose of 0.2 mg/kg was administered subcutaneously as a single dose. On the 7, 22 and 52nd days after the first application, blood sampling and the monitoring of the animals were repeated. Four animals (1 Brown Swiss and 3 Brown Swiss) and two animals (2 Brown Swiss) regressed nearly 90-100 % and 70-80 %, respectively while in other animals (1 Native Black and 2 Brown Swiss) no remission was observed during the observation period. Serum TNF-α and IL-6 levels were determined to have increased on the 7th day and decreased on the 22nd and 52nd days following the administration, but no statistically significance (p>0.05). It was concluded that ivermectin might be effective on clinically recovery and serum TNF-α and IL-6 levels. More comprehensive future studies on higher numbers of animals are warranted