Comparison of effect on postoperative pain of use of xylazine-ketamine or propofol prior to sevoflurane-induced inhalation anesthesia in dogs

In this study, it was aimed to compare the effects on postoperative analgesia of xylazine-ketamine combination or propofol to induction for sevoflurane gas anesthesia. The animal material consisted of 14 dogs with limb fracture brought to our clinics. The dogs were divided into two groups of seven. For induction, it was used combination of xylazine HCl (1 mg / kg, iv) - ketamine HCl (2.5 mg / kg, iv) in the first group and propofol (6 mg / kg iv) in the second group. In both groups, dogs were intubated and the anesthesia continued with sevoflurane followed by induction. At the beginning of the operation and at 5, 15, 30, 60, and 90 minutes, body temperatures, respiratory counts, heart rate counts, and oxygen saturates were recorded. Glucose, AST, ALT, BUN and creatinine values were also determined in the blood serum. Heart rate, respiratory rate and body temperature were recorded at 2, 4, 6, 8, 12 and 24 hours after the operation. At the same time postoperatively, the groups were compared according to simple pain definition scale, Melbourne pain scale and Glaskow composite pain scale. Heart rates at postoperative 4th hour were statistically different in the group but similar between the groups. According to simple pain definition scale, Melbourne pain scale and Glaskow composite pain scale, there was a statistically significant difference at postoperative 6th hour in the group I and postoperative 4th hour in the Group II. As a result, it was observed that the analgesic effect of ketamine was longer in the postoperative period compared to propofol