The Relationship of Lipo (a) and Paraoxonase with Diabetes Mellitus

The aim of this review is to examine the relationship between diabetes mellitus and lipoprotein a (lipo a) and Paraoxonase-1 (PON1). For this, the original publications of the last decade have been scanned. Findings showed that; lipo (a) is associated with many chronic and high-mortality diseases. In the studies lipo (a) elevated diseases; myocardial infarction, chronic renal failure, lung cancer, stroke, diabetes mellitus (DM) and diabetic nephropathy. On the other hand, the level of lipoa (a) was found to be decreased in patients with liver cirrhosis. According to the data of these studies, extensive systemic involvement of DM was found to be effective on the level of lipo (a). A similar situation was found between DM and PON1. In addition, PON1 studies were performed with high density lipoprotein (HDL). In all of these studies, it was found that PON1 levels decreased with HDL. As a result many studies conducted in recent years show that; PON1 levels of patients with diabetes mellitus decrease, while lipo (a) levels are increased