Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome

Objective: The aim of study is to investigate the relationship between neuropeptide Y (NPY) and insulin resistance which is important in the pathogenesis of poliycstic ovary syndrome (PCOS). Material and Methods: This study was conducted between May 2012 and May 2013. The study included 45 patients with PCOS and 44 healthy controls at productive age. Insulin, fasting blood sugar, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactine, testestorone, dehydroepiandrosterone sulfate (DHEA-S), thyroid stimulating hormone (TSH), cortisole, estradiol, NPY levels were measured at early follicular phase in patients with PCOS while insulin, fasting blood sugar, prolactine, DHEA-S, TSH, cortisole, 17-OH progesterone levels were measured in control group. Homeostatic model assessment for insulin resistance (HOMA-IR) scores were calculated and antrepometric measures recorded. Pelvic ultrasonography was performed. Results: Fasting insulin levels and HOMA-IR scores showed insulin resistance to be higher in obese patients with PCOS than healthy control subjects and patients with normal weight PCOS. NPY levels found to be higher in obese-overweight patients with PCOS than healthy control subjects and patients with normal weight but it was not statistically significant (P>0.05). NPY levels did not differ in patients with and without insulin resistance. Conclusion: No correlation dedected between insülin resistance and NPY levels but NPY levels were high in overweight PCOS patients