Protective Effect of Prunus laurocerasus L. Fruit Extract Against Indomethacin-Induced Gastric Ulcer in Rats

In the present study, it was aimed to investigate the protective effects of Prunus laurocerasus fruit extract in the indomethacine-induced gastric ulcer model, which one of the non-steroid anti-inflammatory drugs. Experimental animals were divided into four groups (Control, Prunus laurocerasus, Indomethacine and Omeprazole groups). The groups I and III was given isotonic saline, the group II was given 500 mg/kg Prunus laurocerasus extract and the group IV was given 5 mg/kg omeprazole orally. On the 11th day of the study, a single dose of 100 mg/kg indomethacine was administered orally to the II, III and IV groups. The levels of cyclooxygenase - 2 (COX-2) and C - reactive protein (CRP) increased significantly in indomethacine group (P<0.001), while significantly decreased with the application of Prunus laurocerasus (P<0.05, P<0.001 respectively) and omeprazole (P<0.01, P<0.001 respectively). It was determined that interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels were increased in the indomethacin group (P<0.05). It was detected that IL-6 and TNF-α levels decreased with both Prunus laurocerasus and omeprazole administration, but these decreases were not statistically significant. In conclusion, it has been detected that Prunus laurocerasus has an omeprazole-like effect, which is one of the standard drugs in the market, when lowering CRP and COX-2 levels in gastric ulcer