Oxytocin Effect on Sepsis-induced Experimental Rat Renal Failure Model: A Histological and Biochemical study

We aimed to investigate the therapeutic role of Oxytocin (OT) in sepsis induced rats and its effects on kidneys. Sepsis was induced in 24 of them by cecal ligation-perforation (CLP) method. One of the groups of CLP did not recieve any treatment while either saline 1 ml/kg or OT 0.4 mg/kg was applied intraperitoneally to the other groups within the first hour of surgery. 8 rats were sham-operated and 8 rats were spared as control group. Plasma TNF-α, CRP, MDA levels, total antioxidant capacity (TAC), creatinine level and peripheral leukocyte (WBC) counts were measured. TNF-α, CRP, MDA levels and WBC counts were significantly increased in CLP and CLP-saline groups, on the contrary they are decreased in CLP-OT group. Histopathologically loss of brush border, tubular dilatation and mononuclear cell infiltration was significantly decreased in CLP-OT group but there was no significant difference in erytrocyte extravasation and cast formation when compared to CLP and CLP-saline groups. Our results indicate that OT may have a therapeutic value in limiting sepsis induced inflammation and organ damage