Quantitative Determination with Multivariate Calibration Methods Clarithromycin, Amoxicillin and Lansorazol in Used in Helicobacter pylori Treatment on Human Urine Sample

In this study, clarithromycin, amoxicillin, and lansoprazole agents for the treatment of Helicobacter pylori, which has a role in chronic active gastritis and peptic ulcer disease, has been determinated by the simultaneous spectrophotometric method. Multivariable calibration methods - chemometric methods have been successfully applied to the obtained data. Benefiting from the relationship between the absorbance and the concentration, with the aid of the synthetic mixture, in the urine sample was subjected to the determination of each active substance and the data were analyzed by MLR (Multi Linear Regression), PLS (Partial Least Squares Method) and PCR (Basic Component Regression). The MLR (Multiple Linear Regression), PLS (Partial Least Squares Method) and PCR (Principal Component Regression) are the methods of chemometric calibrations and the results obtained with these methods are extremely fast and most reliable