Henoch-Sch？nlein Purpura Nephritis in Children

Henoch-Sch？nlein purpura is a vasculitis commonly seen in children and holding small diameter vessels. It manifests with skin, joint, gastrointestinal system and renal involvement. It is usually a self-healing disease other than renal involvement. Kidney involvement is frequently seen in 30-50% children with Henoch-Sch？nlein purpura. Risk factors for renal involvement were over 7 years of age, severe gastrointestinal findings, and long duration of purpura. Renal involvement can be seen in various clinical forms ranging from microscopic and/or macroscopic hematuria, proteinuria, rarely nephrotic syndrome, acute nephritic syndrome, hypertension and acute renal failure. Henoch-Sch？nlein purpura nephritis and IgA nephropathy are diseases related to the storage of glycosylated IgAl in glomeruli. Disease renal involvement may improve without sequelae due to treatment, as well as severe crescentic glomerulonephritis and chronic renal failure. Therefore, renal involvement is the most important finding that determines the prognosis of the disease. In this review, renal involvement and treatment of Henoch-Sch？nlein purpura nefritis has been discussed