Relationship of Inflammation and Hemogram Parameters in the Activation of Inflammatory Bowel Diseases

Aim: The evaluation of inflammatory bowel diseases (IBD) is based on a combination of clinical examination, laboratory marker and colonoscopic findings. There is no any gold standard test and cost effective, easy applicable markers are required. This present study aimed is determined the relationship between inflamation parameters and hemogram parameters in the IBD. Material and Method: The present study included patients at ≥18 years of age with IBD, who presented between January 2010 and December 2015 and medical records of all patients were retrospectively assessed. Chron Disease (CH) Activity Index for the assessment of activity of CH and SEO Clinical Activity Index for the assessment of activity of ulserative colitis (UC) were used. Additionally, hemogram, C-reactive protein (CRP) and eritrosit sedimentation rate (ESR) of all patients were evaluated. Results: In this study 74 (39.57%) patients with the CD group and 113 (60.43%) patients with the UC group and total of 187 patients with IBD included. Twenty nine (39.19%) patients with CD and 42 (37.17%) patients with UC were in activation period. The platelet count and RDW were found to increase in the activation period of both disease (p=0.001 and p=0.0001 for CD; p=0.001 and p=0.0001 for UC, respectively). In remission period, while there were positive relationship CRP and ESR with platelet counts in the CD group, the positive relationship CRP with leucocyte count was found in the UC group. (p=0.025, p=0.044 and p=0.003 respectively). In the activation period, there were associated CRP and ESR with RDW in the UC group and the correlation between CRP with platelet count in the CD group was determined (p=0.015, p=0.019, and p=0.025, respectively). Conclusion: Platelet count and level of RDW in the hemogram parameters, which a cost effective method for clinical practice, increase in the activation period of CD and U