The Effects of Lifestyle Modification and HMG-Coa Reductase Inhibitor Treatment on Blood Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Levels Among Patients with Isolated Hypercholesterolemia

Isolated hypercholesterolemia is a frequent condition in the general population. It is managed mostly by therapeutic lifestyle intervention and/or statin treatment. TWEAK is a cytokine from the TNF superfamily and plays a role in tissue regeneration in acute period; it is also involved in tissue damage in chronic period. In this study, we investigated plasma TWEAK levels of participants with isolated LDL cholesterol elevation in response to first 12 weeks of lifestyle modification, and 12 weeks of statin treatment. In conclusion, plasma sTWEAK level increased in dyslipidemia patients who were able to reach target LDL levels after therapeutic lifestyle modification. However, correcting dyslipidemia with statin was not associated with any change in plasma sTWEAK level