Synthesis and Characterization of the Novel Thiophene Derivatives

The use of thiophene derivatives that have a stable structure in agriculture, food and pharmaceutical industries has revealed the necessity of synthesizing different derivatives. For this purpose, in the current study, some substituted thiophene derivatives have been designed and synthesized. The characterization of the synthesized compounds was determined by spectroscopic methods. The possible antimicrobial activities of these compounds (3-9, 10a-e, 11-13) were measured by disc diffusion method against gram positive (Bacillus subtilis ATCC 6633, Staphylococcus aureus 6538) and gram negative (Enterobacter aerogenes ATCC 13048, Escherichia coli) bacteria. The synthesized substituted thiophene compounds do not showed any antibacterial activities against test bacteria