The Rational Approach to a Patient with Hypersensitivity to Non-steroid Anti-inflammatory Drugs

Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonlyused drugs in childhood and are the second most common drugs after antibiotics indrug related hypersensitivity reactions. NSAIDs induce hypersensitivity reactionsin sensitive individuals varying in timing, organ involvement and severity. Hypersensitivity reactions to NSAIDs are classified as allergic (caused by immunological mechanism) and non-allergic (non-immunological) reactions according to the underl-ying mechanism. The diagnosis of NSAIDs hypersensitivity is usually based on clinical history, but patients who have been evaluated with history alone may be misdiagnosed as drug allergy. It is recommended to evaluate the patient with detailedhistory, physical examination and standardized diagnostic tests for definitive diagnosis