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-  2019 

The prognostic effects of new eighth staging system for stage III non-small cell lung cancer

Keywords: kü?ük hücreli d??? akci?er kanseri,prognostik fakt?rler,radyoterapi,evreleme

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Abstract:

Aim: The eighth tumour, node and metastasis (TNM) staging system for lung cancer was published in January 2017. To compare the newly released 8thversion of TNM staging system with 7th version of TNM staging system in stage III non-small cell lung cancer patients (NSCLC) treated with curative chemo-radiotherapy (CRT) and to evaluate the survival differences between the groups were the aims of this study. Material and Methods: Between January 2010 and January 2017, stage III NSCLC patients who were treated with curative CRT were identified retrospectively. Changes in T-stage and TNM-stage were according to 8thstaging system were recorded. Survival analysis were performed by using T-stage, N-stage and TNM stage in each staging system, respectively. Results: One hundred and twelve patients were included in this study. Of these 33 patients (30%) showed change in T-stage, whereas 47 patients (42%) had change in TNM stage. Advanced age, distant organ metastasis during follow-up, TNM stage and N-stage progression was found as independent prognostic factors affecting survival. Conclusion: According to 8th TNM staging system, subdivision of T-stage by tumour size did not affect the survival parameters in locally advanced NSCLC patients. On the other hand, we found significant survival difference between stage IIIa and IIIc. In regards of survival, although there was a significant difference between patients with IIIa and IIIc, and almost significance between patients with IIIa and IIIb, there was no significance between stage IIIb and IIIc patients. Having N3 nodal disease was found to be an independent prognostic factor of survival

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