Neonatal Hemolytic Disease Associated with Subgroups of Non-Rh ‘D’: Single Center Experience

High bilurubine levels resulting form hemolysis of erythrocytes, it causes a disease called ‘Hemolytic Disease of Newborn ’ in neonatal period. The most common causes of Hemolytic Disease of Newborn are incompatibility of ABO and Rh D blood group systems. According to previously reports also non-Rh D subgroups (C, c, E, e) and with them 50 different erythrocyte antigens can be related with Hemolytic Disease of Newborn. We want to report that 16 patients with non Rh D subgroup incompatibility and their clinical progresses. We studied to patients with Hemolytic Disease of Newborn or prolonged jaundice Janunary 2014 to December 2017 in our hospital. We examined to 16 patients whom treated or followed-up with non Rh D subgroup incompatibility. Retrospective file screening revealed a total of 16 cases of non- Rh D subgroup incompatibility recorded. The mean hemoglobin level was 15.1 ± 3 (9.8-19.1 gr / dl) and total bilurubin level was 15.8 ± 3.8 (9.6-22 mg / dl) at admission day in the patients. The mean admission day of the patients was 9.6 ± 8.4 (2-26 days). In eleven patients, a non-D subgroup incongruity (two 'C', four 'c', and five 'E') in Rh patients, two subgroups (three 'c-E', one 'c- C-e '). Direct or indirect antibody screening tests were positive in five (31%) patients. Indirect antibody screening as well as ABO and Rh phenotyping in pregnancy may detect major blood group incompatibilities as well as antibodies related to the Rh system non-D subgroup and other erythrocyte antigen systems. Positivity of direct or indirect antibody screening tests is a factor affecting clinical course. Pregnant women should be screened with IAT in the first trimester for non-Rh subgroup and Kell blood group incompatibilities that may lead to clinics that can progress to hydrops fetalis