Effects of L-NAME and Vitamin E on Lipid Profile and Liver Function Tests in Rats Exposed to Cigarette Smoke

Cigarettes are used by millions of people and directly harm the environment and other living things. Because of the thousands of harmful substances in it, it destroys many organisms such as liver, heart and lung through different metabolisms. In this study, it was aimed to evaluate the levels of certain blood parameters that changed as a result of oxidative stress resulting from exposure to cigarette smoke from commercial cigaratte through inhalation with the application of Vitamin E and L-NAME. In the study, 45 male Wistar albino rats were divided into five group and each group had 9 rats. Cigaratte smoke was administered by inhalation in special cages, 200 mg/kg-BW Vitamin E and 50 mg/kg-BW L-NAME was administered by intraperitoneal during 42 days. On day 43, blood samples were taken from the rats. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), Triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and cholesterol levels were examined in blood samples. In the cigaratte smoke group; It was observed significant increase in LDL-C, triglyceride, ALT, AST and total cholesterol levels(p <0.05) and significant decrease HDL-C levels compared to the control group(p <0.05). ALT, AST, Triglyceride, LDL-C and cholesterol levels decreased and HDL-C level increased in treatment groups(p<0,05). Exposure to cigaratte smoke has been found to cause adverse changes in some blood parameters. It was observed that these adverse changes could be normalized by L-NAME and Vitamin E application