Effect of different exercise model on inflammatory predictors and metabolic parameters in experimentally induced type 2 diabetes model

Purpose: It was aimed to compare the effect of aerobic exercise and resistant exercise training on metabolic parameters and inflammatory predictors in rat type 2 diabetes model in our study. Methods: The study was performed on 14 male rats with type 2 diabetes. The subjects were divided into three groups as aerobic exercise group (N=5), resistive exercise group (n:4) and control group (N=5). The aerobic exercise group were performed 45-60 minutes of swimming training, resistance exercise group were adapted to climb stairs with weights that were 75-100 % of the body weight attached to their tails for 6 weeks 3 times a week. The blood glucose level was determined by glucometer by taking blood from the tail vein. After exercise training, the metabolic parameters (cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), hemoglobinA1c (HbA1c), insulin), inflammatory predictors (tumor necrosis factor alpha (TNF-α), interleukin1-β (IL-1β), interleukin-6 (IL-6) were determined taking blood from the hearts of the subjects under anesthesia by the respective kits. Results: The glucose, TNF-α, IL-1β and IL-6 levels were significantly lower in the aerobic exercise group than in the other groups (p<0.05). The measured others parameters were no significant differences between the three groups (p>0.05). Conclusion: The results of the study can be a pioneer in the planning and implementation of human studies in order to make the right exercise selection in type 2 diabetes. We think that aerobic exercise training improves glycemic control and has an anti-inflammatory effect in the type 2 diabetes model