New predictive parameters of Pfapa syndrome: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio

Objective: This study aims to investigate the correlations between Pfapa (Pf) syndrome or following with Pfapa syndrome diagnosed with neutrophil to lymphocyt ratio (NLR) and platelet to lymphocyte ratio (PLR). Material and Method: The study included 30 patients (16 males, 14 females; mean age 3.33 years; range 1 to 21 years) diagnosed as Pfapa (Pf group) and 30 healthy individuals (15 males, 15 females; mean age 4.01 years; range 1 to 23 years) (control group). Neutrophil to lymphocyte and PLR ratio values of Pf and control groups were calculated and statistically compared. Results: Mean NLR value was 2.21 in the Pf group and 1.75 in the control group with a statistically significant difference (p=0.001). Mean PLR value was 120.76 in the Pf group and 109.82 in the control group with a statistically insignificant difference (p=0.073). Conclusion: Neutrophil to lymphocyte ratio value may be used as a novel marker that is easily administered in patients with Pfapa Syndrome and obtained with low-cost tests. New studies with larger patient series are needed for the value of PLR