The Relation Between Congenital Hypothyroidism and Parental Age

Objective: In this study, we aimed to evaluate the relationship between thyroid dysgenesis and parental age. Material and Methods: A total of 105 patients with thyroid dysgenesis who were between 0-17.9 years of age were studied. The age of the patients and their parents, gender, parental consanguinity, family history of congenital hypothyroidism, clinical and laboratory findings were recorded. Control group consist of six healthy children for each patient, considering their birth dates. Results: A total of 105 patients (56 females, 53.3%) with thyroid dysgenesis and 630 controls were included in the study. Hypoplasia was detected in 50 cases (46.6%), ectopia in 26 cases (24.8%), aplasia in 20 cases (19.0%) and hemiagenesis in 9 cases (8.6%). The mean maternal age of the patients with thyroid dysgenesis was 27.87±5.36 years, which is significantly higher than the control group (p<0.05). There was an increased risk of having a baby with thyroid dysgenesis in the 28-31 years and > 32 years age groups (p<0.05). Conclusion: Our study showed that maternal age was higher in the patients with thyroid dysgenesis than in the control group