What is the Role of Probiotics in Preventing Hospital Infections?

Abstract Probiotics are defined as live microorganisms of human origin that are able totolerate the hostile gastrointestinal environment such that they persist in the loweralimentary tract to confer a health benefit to the host. Metaanalysis of RCT sho-wed that LGG at a dose of 109 CFU/day is effective in prevention of nosocomial diarrhea in children. In 2014 metaanalysis the use of probiotics decreased the incidence of VAP from 29 to 21 percent. However no significant differences in mortality, length of ICU stay, or duration of mechanical ventilation were detected. However quality of evidence is low. Available results do not provide sufficient evidence to draw conclusions regarding the efficacy or safety of probiotics for the prevention of VAP