A Mild Type Propofol Infusion Syndrome Presentation in Critical Care

Propofol infusion syndrome (PRIS) is a rare but fatal disease. It was occured mostly after high dose of propofol infusions for long times. Metabolic acidosis, hypotension, myoglobinuria, elevated muscle and liver enzymes, cardiac arrhythmias, cardiac arrest are common manifestations of the syndrome. This case report concluded a mild type of PRIS which was presented after low dose (25–50 mcg/kg/min) infusion for long time. In this case significant metabolic acidosis, hypotension and arrhythmias were not detected during drug infusion. Syndrome was manifested with only significantly elevated AST, ALT, CK, CKMB, LDH levels. Persistence of these findings during propofol infusion without patient’s further clinical impairments defined as mild type of PRIS. In addition, the improvements in the biochemical parameters deteriorated after the drug was discontinued proved the validity of our diagnosis