Effects of Chitosan Acetate on Early Bone Healing in The Rats That Create Bone Defect

Aim: Bone healing is a complex process which includes pathophisiologic events that need a multidisciplinary aproach. Because of that most authors have studies on this process. The agents which effect the bone healing positively, have a clinic usage. The best material to use for bone healing have to be effected on bone repair, and easy to use. In our study, we aimed to investigate the effects of Chitosan Acetate Bandage on bone healing. Materials and Methods:Two separate study groups were formed each one including ten rats that crate defects on their tibias. In the first group, the defect had been irrigated by serum phisiologic and the bone biopsies had taken form bone on the seventh day. In the second group, Chitosan Acetate Bandage had applied to the defect and the bone biopsies had taken form bone on the seventh day. The samples evaluated histopathologically for osteoblastic activite, inflamatory response and fibrosis scores. Ki kare test was employed to statistically analysis of the data and the significance line accepted as p<0.05. Results:Osteoblastic activite (Stage 4) and inflamatory response (Stage 4) were statistically significant high in Chitosan group according to normal salin group. However there were no statistically significant results for fibrosis scores (Stage 3, 4) between two groups. Conclusion:We determined positive effects of Chitosan Acetate on rats, that have bone defects by histopathologic evaluations