Evaluation of Protein Oxidation Products in Patients With Chronic Renal Failure Receiving Dialysis or Not

DOI: 10.26650/experimed.2018.430561 Objective: In this study, control (n=35) and groups were formed to evaluate the levels of blood protein oxidation products in patients with chronic renal failure (CRF) who did and did not receive replacement therapy and to compare the patients with healthy subjects. Material and Method: The groups were the CRF (n=36) group that did not receive replacement therapy, patients who were undergoing hemodialysis (HD) (n=64), and patients who were undergoing peritoneal dialysis (PD) (n=21). These groups were evaluated for the production of advanced oxidation protein product (AOPP) and advanced glycated end product (AGE) levels. Results: As results, the AOPP and AGE values of all groups increased compared to the control group, except for the AGE levels of the patients with CRF who did not receive replacement therapy. The most significant increase was found in the HD patient group. No relationship was detected between the AOPP and AGE values in any group. Conclusion: According to these results, CRF is accompanied by oxidative stress, and the oxidative stress is much more severe in patients with CRF receiving replacement therapy, particularly in patients undergoing HD. Is unknown if the results of patients undergoing HD were affected by the presence of diabetes