IL-10 and IL-17 Gene Polymorphisms in Adult Idiopathic Thrombocytopenic Purpura

Objective: Interleukin 10 (IL-10) and interleukin 17 (il-17) cytokine gene polymorphisms were investigated in many autoimmune diseases and there were significant results in some studies but there were a few published studies on IL-10 and il-17 gene polymorphisms in idiopathic thrombocytopenic purpura ( ITP). In this study, we aimed to evaluate the IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms and their serum levels in adult patients with ITP. Materials and Methods: The IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms in 50 patients with ITP and 51 healthy control groups were determined after DNA isolation and serum levels of these cytokines were measured by ELISA method in 32 patients with ITP and 32 healthy volunteers. Results: There was no statistically significant difference in IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms between the patients and control groups, whereas serum IL-10 levels were found to be statistically significant higher in ITP patients than control group (p=0.003). Serum IL-17 levels were similar in patients and control groups. In addition, age, sex, response to treatment and platelet values at diagnosis were compared between the groups, but there was no statistically significant difference between the groups. Conclusion: In our study, IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms were not found to be different in patients with ITP compared to healthy subjects, although IL-10 levels were found to be higher in the ITP group than healthy group. When we look the datas in the literature, we think that more studies with larger series are needed in this field in order to clarify the importance of cytokines in the diagnosis and follow-up of ITP