The Effect of Proton Pump Inh？b？tor Usage on the Incidence of Blastocystis sp.

Objective: Blastocystis sp. is one of the most common intestinal system protozoa in humans and it is infected with contaminated water and food through fecal-oral path. It is known that the proton pump inhibitors (PPI), which is commonly used in gastrointestinal system diseases, increase pH of the stomach. This study aimed to investigate the effect of PPI usage on the incidence of Blastocystis sp.. Methods: This research was performed with 100 patients who used PPI regularly within 1 month, 100 patients who used without any PPI with gastrointestinal complaints sent for routine fecal examination from the Gastroenterology Polyclinic to the Parasitology Laboratory of the Faculty of Medicine of …….. University between January 2013 and June 2013. Control group constituted 100 healthy individuals who did not apply to polyclinics. Stool specimens were examined in detail by the native-lugale method. Results: Blastocystis sp. was detected in 24% of PPI users, 5% of non-users and 8% of control group in the study. In the group using PPI, incidence of Blastocystis sp. was found to be significantly higher ( X2 = 8,883 p<0.001). Conclusion: As a result of our work, it is considered that blastocystosis should not be ignored fort he patient who used PPI. This study that was performed acording to our knowledge, this is one of the first study assessing the relationship between incidance of Blastocystis sp. and the usage of PPI and it is important in term of being a reference forthe studies that will be performed in the future