Evaluation of Serum Hba1c Levels in Premenopausal Women with Iron Deficiency Anemia

The effects of iron deficiency anemia (IDA) on HbA1c levels have not been elucidated. Possible causes include changes in the quaternary structure of hemoglobin and the possibility of facilitating glucose in the β globin chain in the patients with IDA. In our study, it was planned to investigate the effect of IDA on HbA1c in non-diabetic individuals. Ninety-five premenopausal patients aged between 18-46 years who were admitted to our outpatient clinic were included in our study. Forty-five patients with hemoglobin value below 12 mg/dl were classified as patient group and forty-six healthy subjects with hemoglobin value upper 12 mg/dl were classified as control group. The relationship between the hemogram and other iron parameters (iron, total iron binding capacity, ferritin, transferrin saturation) of the study groups were investigated. The mean age of the patients included in our study was 32±10 years in the patient group and 30 ± 8 years in the control group. The HbA1c level was %5.6±0.2 in the IDA group and %5.1±0.2 in the control group.HbA1c level of the control group was The difference between the groups was statistically significant (p <0.001). In our study, HbA1c level was significantly higher in the group with IDA. As a result of our study, it was concluded that IDA and other possible sources of error should be considered when interpreting HbA1c levels. It is thought that effective treatment of RIA will eliminate the negative effects of anemia and the errors that will occur in the interpretation of HbA1c