Investigation of Some Drugs Used in High Blood Pressure Treatment by UV/VIS Spectrophotometric and High Pressure Liquid Chromatographic (HPLC) Methods and Evaluation Of Obtained Data by Chemometric Methods

Various methods have been developed in recent years to determine the active ingredients of drugs used in the treatment of hypertension. In this study, active agents such as quinapril and hydrochlorothiazide were examined with UV/VIS and HPLC methods and to ensure accuracy and precision, studies are supported by PLS and PCR chemometric analyzes. After UV / VIS studies, recovery values of quinapril and hydrochlorothiazide as a result of PCR analysis were 100.56% and 99.85%, respectively; standard deviations are 0.512 and 0.027; As a result of PLS analysis, recovery values were 99.18% and 99.75%, respectively; and the standard deviations were calculated as 0.334 and 0.289. After HPLC studies, the recovery values of quinapril and hydrochlorothiazide as a result of PCR analysis were 100.01% and 99.78%, respectively; the standard deviations are 0.170 and 0.241; As a result of PLS studies, recovery values were 100.57% and 100.51%, respectively; and the standard deviations were found to be 0.462 and 0.706. In this study, the efficacy of UV/VIS and HPLC methods in the simultaneous determination of the drug active substances were examined chemometrically and it is concluded that these methods can be used in studies related to the quality and target suitability of hypertension drugs composed of quinapril and hydrochlorothiazide