Effects of GnRH Antagonist/Letrozole Stimulation Protocol on Outcomes of Intracytoplasmic Sperm Injection Cycles in Poor Ovarian Responders

In this retrospective study it was aimed to compare the effects of letrozole added GnRH antagonist controlled ovarian hyperstimulation (COH) protocol to the intracytoplasmic sperm injection (ICSI) cycle outcomes comparing with previous antagonist COH cycles, in patients with diminished ovarian reserve (DOR) and who did not achieved live birth, Twenty-six patients who underwent COH for ICSI between June 2013 and December 2015 were included in the study. Using the electronic database, the COH protocol characterictics of 26 patients who underwent ICSI with indications of DOR were determined. When letrozole was added in the early follicular phase to the conventional antagonist stimulation protocol, in 26 patients previously performed embryo transfer resulting without live birth , total gonadotrophine dose used was significantly lower in the letrozole cycles (p = 0.035), besides number of the retrieved oocyte, mature oocyte, fertilization rate, number of embryos obtained, transferred embriyo numbers, frozen embriyo numbers and clinical pregnancy rates did not show any significant difference comparing with previous antagonist cycles