Effects of Xylazine-Ketamine, Xylazine-Propofoland Xylazine-Ketamine-Propofol Administrationon Some Physiological Parametersin Sheeps

This study aimed at the investigation of the impact of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol combinations on certain physiological parameters in sheep. The study was carried out on 28 one-year-old, clinically healthy, nulliparous Zom ewes, which weighed 43.27±4.76 kg. The animals were randomly assigned in equal numbers (n=7) to four groups, one of which was maintained for control purposes. Excluding the control group, Group 1 was given xylazine-ketamine (0.1 mg/kg-2.2 mg/kg), Group 2 was administered with xylazine-propofol (0.1 mg/kg-3 mg/kg) and Group 3 received xylazine-ketamine-propofol (0.1 mg/kg-2.2 mg/kg-3 mg/kg) by intravenous route. Physiological parameters were measured in all animals before the administration of the anaesthetic agents (at minute 0), and 5, 10, 15, 30, 45, 60 and 120 min after the administration of the anesthetics. The comparison of the three treatment groups with the control group for the physiological parameters measured demonstrated that the differences detected in heart rate at 120 min in Group 3, in respiratory rate at 5 and 30 min in Groups 1 and 3, in body temperature at 10, 15, 30 and 120 min in Group 2 and at 120 min in Group 3 were statistically significant. It was observed that the sheep well tolerated the alterations that occurred in their physiological parameters, as no disruption was detected in their vital functions