Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders

Non-neoplastic epithelial and stromal changes might be prognostic in early phase of premalignant neoplastic developments of urinary bladder. In this regard, diagnosis and histological classification of these lesions give valuable knowledge for prevention and treatment in both human and veterinary medicine. In Turkey, bovine urinary bladder lesions have been encountered in great ratio even though the small numbers of cases have been observed in other animals. According to our great experiences and field-studies for years concentrating on the topic, inflammatory and neoplastic of pathologies in urinary bladders might be easily developed after long term Bracken fern-consuming cattle. In current study, non-neoplastic cases including mainly epithelial, stromal, vascular, and inflammatory characteristic lesions were identified and described separately. Degenerative, desquamative, cystic, hyperplastic, and metaplastic lesions were found prominently in urinary bladder epithelium. Consecutive lesions comprised stromal changes and vascular lesions characterized with circulatory problems. Accompanying those, remarkable mononuclear cell infiltrations were found in a lot of cases. In conclusion, such kind of non-neoplastic lesions at least should be considered as important as neoplastic lesions because the lesions can have a risk in course of premalignant neoplastic transformation