Effects of Fungicide Propiconazole on Oxidative Stress Parameters and Antioxidant System enzymes in liver of Oreochromis niloticus

In this research, 0.5 ppb and 2.5 ppb effect of fungicide propiconazole in 7 days and 28 days periods in liver tissue of Oreochromis niloticus, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S transferase (GST) antioxidant system enzyme activities and oxidative stress parameters glutathione (GSH) and thiobarbituric acid reagents (TBARS) were determined by spectrophotometric methods. In our study, GSH levels and GSH-dependent GPx and GST activity increased in 7 days. In 28 days, decrease in GSH and increase in GST activities were determined. SOD and CAT activities increased in 7 days and decreased in 28 days. In TBARS levels, the time and concentrations -related increase in the effect of propiconazole According to the results of the study; The effect of propiconazole on antioxidant enzyme activity and oxidative stress parameters in O. niloticus was determined to cause hepatotoxic effect