Determination of Peroxisome Proliferator – Activated Receptor Alpha rs4253778 Polymorphism in Football Players

Approximately 250 regions of our genes, estimated to the total of 20-25 thousand genes, as a rusult of Human Genome Project, have been associated with athletic performance. One of these gene regions that affects endurance performance is the peroxisome – activated receptor alpha (PPARA) rs4253778 polymorphism. We aimed to determine the distribution of PPAR polymorphism in young football players. 64 young Turkish football olayers were enrolled to the study. NA isolations were obtained from buccal cells by using commercial DNA isolation kit. Genotyping is carried out by real-time PCR technique. As a result, 42 of the players were found as GG, 21 players as GC and 1 player as CC genotypes. G allele was counted as 105 and C allele as 23. In our cohort, PPARA GG genotype and G allele, which are associated with power phenotype, were found to be more dominant. We believe that this pilot study among footballers will guide for further studies with an extended number of subjects