Investigation of the Protective Effect of Naringenin on the Cisplatin-Induced Nephrotoxicity in Rats

Naringenin which have a bioactive effect on human health is a natural flavonone predominantly found in grapefruit. In this study, the effects of naringenin on some biochemical parameters in renal tissue in cisplatin-induced nephrotoxicity case were investigated in rats. In this study 35 Wistar albino rats, aged 2 months were used. Rats were randomly divided into 5 groups each consisted of 7 rats,; 1.group (control) 1 % DMSO i.p, 2.group (Cis), one dose cisplatin., 7 mg/kg/ i.p, 3.group (NG20) naringenin, 20 mg/kg/ day /i.p, 4.group, (Cis+NG20 ) one dose cisplatin 7 mg/kg/ i.p + 20 mg/kg/day./i.p naringenin, 5.group (Cis+NG40) one dose cisplatin 7 mg/kg/ i.p + 40 mg/kg/day./i.p naringenin were administered for ten days. At the end of the study biochemical analyses were made on samples of kidney tissues. Kidney tissue levels of TOS, OSI, MDA, AOPP, 8-OHdG ve NRF-2 were increased (P<0.05) and TAS and GSH levels (P<0.05) were decreased significantly in cisplatin group (2. group) compared with control group. As naringenin significantly reduced nephrotoxicity in cisplatin-induced rats and nephrotoxicity could be controlled with naringenin