Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits

The aim of this study was to determine of the effects of midazolam, ketamine and isoflurane anesthetic agents on tear production and intraocular pressure in rabbits. In this study twenty healthy (n=20) male white New Zealand rabbits (mean weight 2.20 ± 0.50 kg, age 16 weeks) were used. Anesthesia was performed intramuscular (IM) midazolam 3 mg/kg, and ketamine 30 mg/kg in group I. In second group (Group II), after midazolam and ketamine injections isoflurane 2% was used for general anesthesia. After anesthesia means intraocular pressure (IOP) decreased in both groups. Intraocular pressure in first group (Group I) was 10.3 ± 0.85 mmHg (right eyes), 11.4 ± 0.95 mmHg (left eyes) while it was 8.5 ± 0.85 mmHg (right eyes), 8.3 ± 0.85 mmHg (left eyes) n group II. The result of this study show that systemically used midazolam, ketamine and isoflurane anesthetic agents decrease IOP and tear secretion in rabbits