The Protective Effect of Melatonin on Uterine Tube in Polycystic Ovary Syndrome: Histological Study

Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder that affects reproductive health adversely. The use of antioxidants become widespread among treatments. We aimed to investigate the possible changes of uterine tube which play a key role in the gamete transport and fertilization, in the experimental PCOS model and also the protective effects of exogenous-applied melatonin on these changes. 6-8 weeks, 32 Sprague Dawley female rats were divided 4 equal groups: Sham Control Group (%1 CMC/day/gavage), Melatonin Group (2 mg/kg/day/subcutaneously), Experimental PCOS Group (1 mg/kg Letrozole [Dissolved in %1 CMC]/day/gavage) and Experimental PCOS+Melatonin Group (1mg/kg Letrozole [Dissolved in %1 CMC]/day/gavage + 2 mg/kg/day/subcutaneously). After the 21 days experiment, uterine tube tissues were taken and examined with Hematoxylin-Eosine. Statistical data were prepared by measuring epithelial height and the wall thickness of the tissues. Kinocilium, epithelium degenerations and epithelium proliferation were seen in uterine tube in the experimental PCOS model. It was observed that protectively applied melatonin inhibited these degenerations significiantly. Exogenous melatonin administration could be used for protection the uterine tube against experimental PCOS