A Retrospective Analysis of Cases with Localized Amyloidosis of the Vesicula Seminalis and the Ductus Deferens

Amyloidosis is a heterogeneous group of diseases characterized by accumulation of amyloid protein in the extracellular matrix, which may be systemic or localized. Localized amyloidosis is a non-neoplastic disease that results from limited amyloid accumulation to a single tissue, and clinically mimics malignancies forming a localized mass. In this descriptive study, we aim to report our series of localized amyloidosis in the vesicula seminalis and the ductus deferens as well as clinicopathologic characteristics of these tumors in literature data. In this study, we examined the localized amyloidosis cases of the vesicula seminalis and the ductus deferens, diagnosed between 2013 and 2018 by searching the archives of Uludag University, Faculty of Medicine, Department of Pathology. The sites where localized amyloidosis was detected include only the vesicula seminalis in four cases who underwent a cystoprostatectomy procedure, both the vesicula seminalis and the ductus deferens in five out of six cases with a prostatectomy procedure, and only the ductus deferens in one case. The deposits in the form of subepithelial, eosinophilic, amorphous and homogeneous substance were treated with Congo Red staining in all cases. The histochemical treatment with Congo Red yielded tile reddish staining in these areas, making them appear apple-green on the polarized light microscopy. In conclusion, localized amyloidoses are relatively rare in the vesicula seminalis and the ductus deferens, although they can be detected at very different locations. Since they are incidentally detected, it is important to evaluate a case in terms of amyloid deposits while examining biopsy specimens, as well as staining with Congo Red when necessary