Factors Affect？ng The Appet？te-Sat？ety Metabol？sm

Abstract Balance between appetite and satiety is important for the weight control and diet of individuals. Appetite is defined deliberately a desire against food and is regulated by gastrointestinal and central systems such as pancreas, and adrenal glands and nervous system. The desire to eat is influenced by psychological factors as well asphysical factors. Especially the children who reject proper food in take may have eating disorders in future. One of the basic conditions of being alive is to meet the energy needs. People, like many other species, they meet the energy needs through foods. Energy intake is influenced by appetite enhancer (oroxigenic) and appetite suppressants (anorexigenic) factors. Appetite control is a function of the hypothalamus of the brain. The signals released from gout, pancreas and adipose tissue are transmitted to the hypothalamus. In the hypothalamus, lateral hypothalamic area (LHA) and ventromedyal hypothalamus (VHM) act as the hunger and the satiety centers respectively. Loss of sensitivity to the hormones and their metabolites in these regions cause the loss of balance between the energy intake and expenditure, and consequently result in hipophagia and weight loss or obesity and weight gain. In this review article, the effects of hormones and metabolites which suppress the appetite and trigger eating were evaluated based on theliterature