Nosocomial Sepsis in Premature ？nfants at Neonatal ？ntensive Care Unit.

Aim: We aimed to establish the nosocomial sepsis development rate, risk factors, and most frequently found microorganisms in premature infants observed in Neonatal Intensive Care Units (NICU). Materials and Method: A total of 170 premature infants with 46 from nosocomial sepsis group (NSG) and 124 premature infants from the control group (CG) were included in this study. Gender, birth weight (BW), gestational age (GA) hospital stay and birth types, the laboratory and clinical findings of all patients were recorded. Blood, cerebrospinal fluid(CSF), endotracheal aspirate (ETA), throat, urine, and umbilical culture samples of the patients believed to have sepsis were obtained. Results: As a result of the logistic regression analysis conducted to establish sepsis risk factors, hospital stays, low BW, lack of sucking, ventilation treatment, and blood transfusion were established to statistically significantly increase nosocomial sepsis. In addition, vomiting, fever, apnoea, convulsion, meningitis, and hypothermia that are among clinical symptoms were found as the significant risk factors in terms of sepsis development. CRP, MPV↗ and TG(+) were higher in NSG and were found as statistically significant. Of the nosocomial sepsis patients, growth was observed in the blood of 50%, and in urine of 20.37%. While klebsiella pneumonia was isolated in 11 of the 46 patients (40.74%), also observed were S. Aureus(18.51%), pseudomonas, and E. coli(11.11%) growth, respectively. Conclusion: Since nosocomial sepsis constitutes a significant cause of morbidity and mortality in infants, we believe that establishing risk factors and infection factors and taking necessary precautions would lower morbidity and mortality