Effect of Tianeptine on Oxidative Renal Damage Induced by Ischemia Reperfusion in Rats

Renal ischemia-reperfusion (I/R) damage can develop following major surgical conditions such as shock, trauma, and renal transplantation and causes acute renal failure. Kidney I/R damage is known to be a pathological process that begins with the touch free of oxygen and continues with the production of free oxygen radicals. We will investigate the effect of renal I/R injury on tianeptine, an atypical antidepressant drug with antioxidant properties. There was no information on the effect of tianeptine on I/R-induced kidney damage in the literature. The aim of the present study was to investigate the effect of tianeptine on oxidative kidney damage induced by I/R in rats. Albino wistar male rats were divided into groups as renal I/R (RIR) group, 25 mg/kg of thianeptine+renal I/R (TIR-25) group and sham operation (SG) group. The I/R procedure (one hour ischemia, three hours reperfusion) was performed with 25 mg/kg intraperitoneal thiopental sodium anesthesia. Oxidative damage was assessed by malondialdehyde (MDA) and total glutathione (TGSH) measurements in kidney tissue. Biochemical test results showed that the I/R process increased the amount of MDA in the kidney tissue and decreased the tGSH. Tianeptine significantly prevented the increase of MDA and decrease of tGSH in kidney tissue after I/R. Our experimental results suggest that tianeptine may be useful in preventing I/R-induced oxidative renal injury