Serum Cystatin-C Levels Could Be Predictor of Diastolic Heart Failure

Abstract: Aim: Formerly diastolic heart failure eveluated as sistolic heart failure but nowadays we know their distinc patophisyolojical mechanism.In this study we tried to Show the relations between diastolic dysfunction and serum cyctatin C consantrations. Methods : We included the individuals who admitted to cardiology clinic of Düzce University Medical Faculty between May 2010 and September 2010. We evaluate the serum cystatin C consantrations and diastolic dysfunction among 88 person. we evoluated the diastolic parameters with 2D echocardiography , TDI and PW doppler mesuraments.The 88 study participants were categorized according to their diastolic parameters into three groups normal ,grade 1 and grade 2. We made cystatistical analysis in each groups and parameters. Results: ？n this study the participants who has grade 1 and grade 2 diastolic disfunction were compaired with normal participants (who has normal Diastolic function) according to their serum cycstatin C consentrations.We shown the sytatisticly significant incrise of serum cycstatin C levels in the group of diastolic disfunction Grade 1 and Grade 2.(nomal-grade 1:p<0,0001,normal-grade 2:p<0,004). And we find that the cut off ratio for Cystatin C was 0,997 ng/ml . On this point Cystatin c was %80 specific and %78.95 sensitive for diastolic disfunction. Conclusion: Serum Cystatin C levels may be useful in the early detection and monitoring of diastolic dysfunction. Key Words: Diastolic heart failure, Cystatin C, Echocardiograph