Kikuchi-Fujimoto's Disease: 3 Cases

Kikuchi-Fujimoto's disease or histiocytic necrotizing lymphadenitis is a self-limited, benign disease that often occurs in young women. Usually it presents with cervical lymphadenopathy. An extranodal extension of the disease, including involvement of skin, eye, and bone marrow localizations, has been rarely described. Most patients have leukopenia or neutropenia. Need for lymph node biopsy for diagnosis. Histological examination revealed numerous CD68+/ myeloperoxidase (MPO) + histiocytes, CD68 + / CD123 + plasmacytoid dendritic cells. The disease can be clinically mixed with systemic lupus erythematosus, tuberculosis or lymphoma. It may rarely coexist with SLE, and may be associated with bone marrow or extensive lymph node involvement. Here, we present 3 cases in one center and different clinical course