Synthesis and Antifungal Activity of New Nitrobenzofuran Derivatives

The object of present study is to assess anticandidal activities of some new aryl (5-nitrobenzofuran-2-yl)keton and ketoxime compounds. Eight aryl (5-nitrobenzofuran-2-yl)ketones and ketoximes were synthesized. IR, 1H-NMR and HR-MS spectroscopic data, performed the structure elucidation of the synthesized compounds. Anticandidal activities of the all synthesized compounds were studied. Compound 2c bearing methoxy group on phenyl ring showed the highest activity with MIC value of 3.12 μg mL-1 against Candida albicans and Candida glabrata. None of the compounds activity results were equal to or better than that of the control compounds ketoconazole and fluconazole. However, compound 2c displayed a promising anticandidal activity