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-  2015 

Comparison of therapeutic effect of acarbose and metformin in patients with type 2 diabetes mellitus

DOI: http://dx.doi.org/10.14725/gjnr.v3n3a1182

Keywords: Type 2 diabetes mellitus, Acarbose, Metformin, Blood glucose

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Abstract:

Objective: To observe the clinical effect of the Acarbose and Metformin in the treatment of type 2 diabetes mellitus. Methods: 80 patients with type 2 diabetes mellitus, who were poorly controlled by diet only or plus sulfonylureas treatment, were randomized into two groups and treated for 16 weeks with either acarbose 50~100mg tid (n=48) or Metformin 250~500mg tid (n=32) respectively. Results: The results showed that both acarbose and metformin led to a reduction of GHbAlc, the mean fasting and 2h postprandial blood glucose levels. The effective rate of reduction of the mean fasting blood glucose level with metformin was higher than that of acarbose (96.9% and 85.7%, P < 0.01), and the effective rate of reduction of the 2h postprandial blood glucose levels with acarbose was higher than that of metformin (97.6% and 93.8%, P < 0.01). The levels of GHba.c were reduced in both groups ( P < 0.01) but without statistically significant difference ( P > 0.05). Conclusion: The two medicines have no insulinotropic effect and do not effect the plasma liquid and the functions of liver or kidney

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