Severe cutaneous reaction induced by Hirudoid: a rare case report

Objective: To explore the clinical characteristics, diagnosis and prognosis of local severe cutaneous reactions as result of the treatment with Hirudoid. Methods: One case of severe cutaneous reactions as result of the treatment with Hirudoid was reported and the relevant literatures were reviewed. Results: The site of puncture of left arm occurred non-leakage phlebitis with local pain after chemotherapy. The patient was applied the Hirudoid to the affected areas 2 times daily. After 2 days, local skin felt a kind of burning pain and it seems to be getting worse. The skin lesions began as pruritic red macules or papules. It became swelled and bleeding after scratching. We considered that the cutaneous reactions were an allergic response to Hirudoid. We discontinued the Hirudoid and desensitization treatment was used on cure, but it failed to respond to the medical treatment. A hot compress with 50% magnesium sulphate solution can reduce swelling and alleviate pain. Scales of skin peel off and weaved the new skin after 10 days. Conclusion: The case of local severe cutaneous reactions as result of the treatment with Hirudoid is very rare. A hot compress with 50% magnesium sulphate solution can help to relieve the discomfort