The influence on coagulant of patients with cancer by PICC placement

Objective: To study the influence on coagulant of patients with cancer by PICC placement. Methods: To test the plasma levels of D-dimer(D-D),prothrombin(PT),activated partial thromplasmtin(APTT),thrombin time(TT),antithrombin(ATⅢ),fibrinogen(Fib) and platelet count by ELISA in 46 patients with cancer in one day before PICC placement, in one day,30 day, and 90 day after PICC placement, and analyses the change feature and clinical significance. Results: (1)The levels of plasma D-D were higher than control group in both pre-PICC placement and post-PICC placement, but there were no differences in both pre-PICC placement and post-PICC placement( P>0.05).(2)The levels of plasma PT, APTT,TT,ATⅢ,Fib and platelet were not different in both pre-PICC placement and post-PICC placement(all P>0.05),and there were no differences from control group.(3)There were no cases with thromboembolism in 48 cancer patients without PICC placement, and 3 cases of thromboembolism occurred among 88 cancer patients treated with PICC placement. But there were no significances( P=0.27). Conclusion: Therelevels of D-D,PT,APTT,TT,ATⅢ, Fib and platelet in patients with cancer did not change in both pre-PICC placement and post-PICC placement. There was no effect of coagulant on patients with cancer by PICC placement. The PICC placement was safe