全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2019 

Self-Assembled Metal–Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes

DOI: https://doi.org/10.1021/acsabm.8b00720

Full-Text   Cite this paper   Add to My Lib

Abstract:

Natural and synthetic membrane active molecules increase the permeability of cell membranes. This can help cells combat multidrug efflux pumps as well as improve signaling and transfection. In this work, thermoresponsive metal–organic complexes (MOCs) have been constructed to transport cell impermeable cargo across the membrane through a pore-aiding assembly. These MOCs can be reversibly controlled as they collapse when the temperature is increased and are simultaneously regenerated when the system is cooled down to room temperature. These ON/OFF molecular valves can be potentially used to overcome multidrug resistance (MDR) in cancer cells and as building blocks for artificial cells

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133